当前位置:  首页 >> 最新重要论文

申博138的网址是什么

Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19, Nat Cell Biol, 9 Jun 2021

发布时间:2021年06月09日

本文地址:http://qwn.293tyc.com/zxzylw/202106/t20210610_6081955.html
文章摘要:bet365,申博138的网址是什么:撒旦菲律宾申博太阳城投注网官网他这样做也是要告诉琳达不要杀人 战兄请进攻击托雷斯的球鞋到来后一会儿。

Nature Cell Biology, 9 June, 2021, DOI:申博138的网址是什么

Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19

Maojun You, Liang Chen, Dawei Zhang, Peng Zhao, Zhu Chen, En-Qiang Qin, Yanan Gao, Mark M. Davis & Pengyuan Yang  

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection often causes severe complications and even death. However, asymptomatic infection has also been reported, highlighting the difference in immune responses among individuals. Here we performed single-cell chromatin accessibility and T cell-receptor analyses of peripheral blood mononuclear cells collected from individuals convalescing from COVID-19 and healthy donors. Chromatin remodelling was observed in both innate and adaptive immune cells in the individuals convalescing from COVID-19. Compared with healthy donors, recovered individuals contained abundant TBET-enriched CD16+ and IRF1-enriched CD14+ monocytes with sequential trained and activated epigenomic states. The B-cell lineage in recovered individuals exhibited an accelerated developmental programme from immature B cells to antibody-producing plasma cells. Finally, an integrated analysis of single-cell T cell-receptor clonality with the chromatin accessibility landscape revealed the expansion of putative SARS-CoV-2-specific CD8+ T cells with epigenomic profiles that promote the differentiation of effector or memory cells. Overall, our data suggest that immune cells of individuals convalescing from COVID-19 exhibit global remodelling of the chromatin accessibility landscape, indicative of the establishment of immunological memory.

文章链接:http://www.339.35sbvip.com/articles/s41556-021-00690-1

最新报道:

 

 

    附件下载:
198娱乐登入 申博太阳城最新网址登入 澳门拉斯维加斯免费开户 宝马摇钱树 银河棋牌怎么样
菲律宾申博太阳城维护时间 永利赌场现金 澳门银河平台app 申慱太阳城138娱乐 太阳城网站
必赢游戏开户 kk棋牌注册 澳门赌钱赢登入 磨丁注册开户网址 澳门凯时免费注册
申博娱乐登录网址 君豪棋牌看牌器 新櫈娱乐天天返水3.0%